The quickly changing coronavirus has spawned yet another super contagious omicron mutant that’s worrying scientists as it gains ground in India and pops up in numerous other countries, including the United States.

Scientists say the variant – called BA.2.75 – may be able to spread rapidly and get around immunity from vaccines and previous infection. It’s unclear whether it could cause more serious disease than other omicron variants, including the globally prominent BA.5.

“It’s still really early on for us to draw too many conclusions,” said Matthew Binnicker, director of clinical virology at the Mayo Clinic in Rochester, Minnesota. “But it does look like, especially in India, the rates of transmission are showing kind of that exponential increase.” Whether it will outcompete BA.5, he said, is yet to be determined.

Still, the fact that it has already been detected in many parts of the world even with lower levels of viral surveillance “is an early indication it is spreading,” said Shishi Luo, head of infectious diseases for Helix, a company that supplies viral sequencing information to the U.S. Centers for Disease Control and Prevention.

The latest mutant has been spotted in several distant states in India, and appears to be spreading faster than other variants there, said Lipi Thukral, a scientist at the Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology in New Delhi. It’s also been detected in about 10 other countries, including Australia, Germany, the United Kingdom and Canada. Two cases were recently identified on the West Coast of the U.S., and Helix identified a third U.S. case last week.

Fueling experts’ concerns are a large number of mutations separating this new variant from omicron predecessors. Some of those mutations are in areas that relate to the spike protein and could allow the virus to bind onto cells more efficiently, Binnicker said.

Another concern is that the genetic tweaks may make it easier for the virus to skirt past antibodies — protective proteins made by the body in response to a vaccine or infection from an earlier variant.

But experts say vaccines and boosters are still the best defense against severe COVID-19. In the fall it’s likely the U.S. will see updated formulations of the vaccine being developed that target more recent omicron strains.

“Some may say, ‘Well, vaccination and boosting hasn’t prevented people from getting infected.’ And, yes, that is true,” he said. “But what we have seen is that the rates of people ending up in the hospital and dying have significantly decreased. As more people have been vaccinated, boosted or naturally infected, we are starting to see the background levels of immunity worldwide creep up.”

It may take several weeks to get a sense of whether the latest omicron mutant may affect the trajectory of the pandemic. Meanwhile Dr. Gagandeep Kang, who studies viruses at India’s Christian Medical College in Vellore, said the growing concern over the variant underlines the need for more sustained efforts to track and trace viruses that combine genetic efforts with real world information about who is getting sick and how badly. “It is important that surveillance isn’t a start-stop strategy,” she said.

Luo said BA.2.75 is another reminder that the coronavirus is continually evolving – and spreading.

“We would like to return to pre-pandemic life, but we still need to be careful,” she said. “ We need to accept that we’re now living with a higher level of risk than we used to.”

Ghosal reported from New Delhi. Ungar reported from Louisville, Kentucky.

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

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India’s official count of coronavirus cases surpassed 20 million Tuesday, nearly doubling in the past three months, while deaths officially have passed 220,000. Staggering as those numbers are, the true figures are believed to be far higher, the undercount an apparent reflection of the troubles in the health care system.

The country has witnessed scenes of people dying outside overwhelmed hospitals and funeral pyres lighting up the night sky.

Infections have surged in India since February in a disastrous turn blamed on more contagious variants of the virus as well as government decisions to allow massive crowds to gather for Hindu religious festivals and political rallies before state elections.

The reported caseload is second only to that of the U.S., which has one-fourth the population of India but has recorded over 32 million confirmed infections. The U.S. has also reported more than 2 1/2 times as many deaths as India, at close to 580,000.

India’s top health official, Rajesh Bhushan, refused to speculate last month as to why authorities weren’t better prepared. But the cost is clear: Many people are dying because of shortages of bottled oxygen and hospital beds or because they couldn’t get a COVID-19 test.

India’s official average of newly confirmed cases per day has soared from over 65,000 on April 1 to about 370,000, and deaths per day have officially gone from over 300 to more than 3,000.

On Tuesday, the health ministry reported 357,229 new cases in the past 24 hours and 3,449 deaths from COVID-19.

Dr. Ashish Jha, dean of Brown University’s School of Public Health in the U.S., said he is concerned that Indian policymakers he has been in contact with believe things will improve in the next few days.

“I’ve been … trying to say to them, `If everything goes very well, things will be horrible for the next several weeks. And it may be much longer,’” he said.

Jha said the focus needs to be on “classic” public health measures: targeted shutdowns, more testing, universal mask-wearing and avoiding large gatherings.

“That is what’s going to break the back of this surge,” he said.

The death and infection figures are considered unreliable because testing is patchy and reporting incomplete. For example, government guidelines ask Indian states to include suspected COVID-19 cases when recording deaths from the outbreak, but many do not do so.

Municipal records for this past Sunday show 1,680 dead in the Indian capital were treated according to the procedures for handing the bodies of those infected with COVID-19. But in the same 24-hour period, only 407 deaths were added to the official toll from New Delhi.

The New Delhi High Court announced it will start punishing government officials if supplies of oxygen allocated to hospitals are not delivered. “Enough is enough,” it said.

The deaths reflect the fragility of India’s health system. Prime Minister Narendra Modi’s party has countered criticism by pointing out that the underfunding of health care has been chronic.

But this was all the more reason for authorities to use the several months when cases in India declined to shore up the system, said Dr. Vineeta Bal of the Indian Institute of Science Education and Research.

“Only a patchwork improvement would’ve been possible,” she said. But the country “didn’t even do that.”

Now authorities are scrambling to make up for lost time. Beds are being added in hospitals, more tests are being done, oxygen is being sent from one corner of the country to another, and manufacturing of the few drugs effective against COVID-19 is being scaled up.

The challenges are steep in states where elections were held and unmasked crowds probably worsened the spread of the virus. The average number of daily infections in West Bengal state has increased by a multiple of 32 to over 17,000 since the balloting began.

“It’s a terrifying crisis,” said Dr. Punyabrata Goon, convener of the West Bengal Doctors’ Forum.

Goon added that the state also needs to hasten immunizations. But the world’s largest maker of vaccines is short of shots, the result of lagging manufacturing and raw material shortages.

Experts are also worried the prices being charged for shots will make it harder for the poor to get vaccinated. On Monday, opposition parties urged the government make vaccinations free to all Indians.

India is vaccinating about 2.1 million people daily, or around 0.15% of its population.

“This is not going to end very soon,” said Dr. Ravi Gupta, a virus expert at the University of Cambridge in England. “And really … the soul of the country is at risk in a way.”

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Associated Press writer Danica Kirka in London contributed to this report.

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

ANIRUDDHA GHOSAL • AP News

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